GS-441524 is a compounded antiviral for treating feline infectious peritonitis (FIP), available through Wedgewood. Trusted by veterinarians and sourced from FDA-registered suppliers, it brings new confidence and consistency to FIP care.
Key Facts
Available in a Flavored Oral Oil Suspension: Customizable flavors for easy administration and compliance.
How It Works: Prior independent studies (linked below) have shown that it interferes with the FIP virus's enzymes or other biological processes.*
Current Treatment Approach: Oral GS-441524 is now widely recognized as the preferred antiviral treatment for FIP and has demonstrated high success rates across effusive, non-effusive, ocular, and neurological presentations of the disease. Published studies and ABCD guidance report treatment success rates frequently exceeding 90% when cats are diagnosed promptly and treated appropriately.
Dosage and Administration: Current ABCD treatment guidance identifies oral GS-44154 as the preferred first-line antiviral for feline infectious peritonitis (FIP). A dosage of 15mg/kg orally once daily is effective for most cats with FIP. Cats with ocular or neurological involvement may require higher doses, such as 20mg/kg once daily or divided dosing of 10mg/kg twice daily, based on clinical response and veterinary assessment. Treatment duration is commonly 6 weeks (42 days), although some cats may require longer courses of up to 12 weeks (84 days) depending on disease severity, treatment response, and monitoring results. Veterinary supervision and regular assessment are recommended throughout treatment.*
Side Effects: According to these independent studies, side effects are mild and infrequent.
Dating: The Beyond-Use Dating for Wedgewood’s GS-441524 is up to 90 days for the oral oil suspension and may ship for office stock in most states.**
Monitoring: Cats should be monitored regularly throughout therapy, including body weight, clinical signs, and laboratory parameters. Dose adjustments may be necessary as cats gain weight during recovery. Resolution of clinical signs, normalization of laboratory abnormalities, and continued improvement in overall condition help guide treatment duration and outcomes.
*We note that Wedgewood’s formulation containing GS-441524 has not been studied in any clinical trials. Wedgewood makes no claims of safety or efficacy with respect to the medications it produces and sells. The information provided herein is for informational purposes only.
**GS-441524 may only be shipped for office stock in states that allow office stock for 503A compounded preparations.
Independent Third-Party Studies
Some practitioners may find the studies which we provide below useful. The medications used in the studies were not provided by Wedgewood Pharmacy and we make no claim that the results found in the studies have any connection with or relevance to the results that may be achieved with any Wedgewood Pharmacy drug. The authors of this study are not endorsing in any manner any Wedgewood Pharmacy product and any implication to the contrary is expressly denied.
"Thirty-two cats with effusive or non-effusive feline infectious peritonitis treated with a combination of remdesivir and GS-441524"
by Green, et al.
“Retrospective study and outcome of 307 cats with feline infectious peritonitis treated with legally sourced veterinary compounded preparations of remdesivir and GS-441524 (2020-2022)”
by Taylor, et al.
"European Advisory Board on Cat Diseases (ABCD). Guidelines for Feline Infectious Peritonitis. Updated 2026."
By Tasker, et al.
"Outcomes of treatment of cats with feline infectious peritonitis using parenterally administered remdesivir, with or without transition to orally administered GS-441524"
By Coggins, et al.
Dosing Calculator
The GS-441524 dosing protocol is based on independent clinical studies. This calculator is a tool that can be used to assist you in determining the dose needed for your unique case. Veterinarian professional and clinical judgement should ultimately determine the final dosing protocol.
"The recent availability of predictably effective antiviral treatments, notably the nucleoside analogue GS-441524, for FIP has totally changed the landscape of this disease for both owners and veterinary teams"
-Tasker, et al., "Feline Infectious Peritonitis: European Advisory Board on Cat Diseases Guidelines"
RACE-Approved CE On-Demand
The Evolution of FIP Treatment: Understanding Compounded Molnupiravir and Its Role in Treating Feline Infectious Peritonitis
Check out our CE session on FIP, now available on demand! Explore clinical presentations, the role of compounding in treatment, and updated research on molnupiravir and GS-441524, with practical tools to expand therapeutic options and improve patient outcomes.
FAQs
What makes Wedgewood’s GS-441524 different from other suppliers?
Wedgewood offers GS-441524 sourced from FDA-registered suppliers with pharmacist support and consistent, high-quality compounding.
Can GS-441524 be used alongside Molnupiravir?
Yes, GS-441524 and Molnupiravir can be used together under veterinary supervision. They offer complementary antiviral mechanisms—GS-441524 blocks viral replication, while Molnupiravir induces lethal viral mutations. This combination or personalized use of one over the other can be adjusted based on patient response. Our pharmacists are available to help develop individualized treatment protocols, even in challenging cases.
Can my practice order GS-441524 for office stock?
GS-441524 can be shipped to hospitals for office stock in all states excep Colorado, Delaware, Hawaii, Louisiana, Maryland, Montana, New York, Oregon, Rhode Island, Connecticut, New Hampshire, New Mexico, South Dakota, and Washington D.C. Veterinarians who work in a state that does not allow compounded medications for office stock can prescribe GS-441524 in a patient’s name.
How long will it take for an order or prescription for GS-441524 to ship, and how long will it spend in transit?
Orders for GS-441524 are expected to ship within 1-2 business days. Time in transit will depend on the shipping method chosen.
Do you ship internationally?
We ship to all 50 states, Puerto Rico, the US Virgin Islands, Canada, Guam, and all US military bases worldwide.
What is the Beyond-Use Dating (BUD) for GS-441524?
The oral liquids will have a 90-day BUD from the date of compounding.
What quality control measures does Wedgewood follow?
We use FDA-registered APIs, rigorous compounding protocols, and maintain strict quality assurance.
Is there a risk of resistance with using GS-441524 or Molnupiravir?
While resistance can develop with any antiviral, using a combination approach or switching between GS-441524 and Molnupiravir under veterinary guidance can help mitigate this risk. Our pharmacists can support personalized strategies.
*We note that Wedgewood’s formulation containing GS-441524 has not been studied in any clinical trials. Wedgewood makes no claims of safety or efficacy with respect to the medications it produces and sells. The information provided herein is for informational purposes only.