Commonly prescribed for: Functional Urethral Obstruction; Malignant Hyperthermia; Canine Stress Syndrome; Exertional Rhabdomyolysis
Species: Dogs, Cats, and Horses
Therapeutic Class: Skeletal Muscle Relaxant
Dantrolene sodium (DS) is a non-centrally acting skeletal muscle relaxant. It interferes with normal excitation/contraction coupling. Although the mechanism of action is not understood completely, it is thought to interfere with the release of calcium from the sarcoplasmic reticulum by interfering with a specific receptor. DS does not interfere with cardiac and smooth-muscle contraction because the mechanism of calcium release in these types of muscle is under different control. DS is used in humans primarily for upper motor neuron disorders. It is metabolized by the liver and excreted in urine.
DS may be used to treat functional urethral obstruction due to urethral spasm in both dogs and cats. It is used for a similar purpose in the emergency care of acute spinal cord injury when the patient has decreased urinary function.
DS is an integral part of the treatment for malignant hyperthermia and canine stress syndrome. In contrast to equine exercise induced rhabdomyolysis, pretreatment with DS is not protective in dogs prone to canine stress syndrome. DS also is mentioned as an adjunct treatment for black widow spider bite.
DS is used as a treatment and as a preventive measure for exertional rhabdomyolysis. In treating exertional rhabdomyolysis, DS decreases muscle spasm and possibly helps prevent further muscle necrosis. Other drugs used concurrently to treat exertional rhabdomyolysis include sedatives, such as Acepromazine or Xylazine, NSAIDs, intravenous fluids, and possibly DMSO. When DS is used within a preventive program, it should be given on an empty stomach prior to exercise. Oral absorption of DS takes about one and one half hours and the half-life is slightly more than two hours. Some clinicians also use DS in the management of horses with back and sacroiliac pain.
Remember to tell your veterinarian about any medications, vitamins, supplements, or herbal therapies that you are giving to your pet.
Oral overdose may cause increased severity of side effects. If recognized promptly, gut emptying protocols should be attempted.
Wedgewood provides medication options that help ensure accurate dosing, especially for hard to medicate pets. Click below for a complete list of Wedgewood’s dosing forms and strengths.
DOSAGE FORM | BENEFITS | STRENGTHS |
---|---|---|
Oral Oil Suspension | Oil based oral suspension with a wide variety of flavoring options. | 5 mg/ml to 100 mg/ml |
Oral Paste | Flavored oral paste, packaged in a dosing syringe. | 100 mg/ml to 250 mg/ml |
Oral Powder | Flavored oral dry dosage form, ideal for mixing in food. | 500 mg to 1 gm |
View all Dantrolene Sodium options