Commonly prescribed for: Anesthetic Protocols
Species: Horses
Therapeutic Class: Centrally Acting Muscle Relaxant
Guaifenesin is a centrally acting muscle relaxant that is used as a part of many anesthetic protocols in the horse. Its mechanism of action is not precisely known but the relaxation of skeletal muscles, mild analgesic and mild sedative properties allows for lower doses of other sedatives and anesthetic agents. Guaifenesin is used for induction before inhalation anesthesia, during inhalation anesthesia and with total intravenous anesthesia (TIVA) for short procedures. Guaifenesin has minimal effects on diaphragmatic function and produces relatively little respiratory depression at normal doses. It is used primarily in horses although it has been studied and is used in other domestic species.
Guaifenesin within a Triple Drip combination also is administered with inhalant anesthesia as a means of reducing the total amount of inhalant used in a given case. This combination of intravenous and inhalant anesthesia is referred to as "balanced anesthesia." Balanced anesthesia has the advantages of less cardiovascular depression, diminished need for additional drugs to support hemodynamics and improved recoveries.
Remember to tell your veterinarian about any medications, vitamins, supplements, or herbal therapies that you are giving to your pet.
Anticholinesterase drugs such as physostigmine are contraindicated. (Plumb 2005)
Guaifenesin is relatively safe. The margin of safety is reported to be three times the normal dose and cardiovascular side effects are rare. Signs of overdose include apneustic breathing, nystagmus, hypotension and increased muscle rigidity. Although there is no specific antidote, Guaifenesin has a relatively short half-life (60 to 85 minutes) (Plumb 2005). Supportive treatment should be instituted while the drug is being cleared.
Wedgewood provides medication options that help ensure accurate dosing, especially for hard to medicate pets. Click below for a complete list of Wedgewood’s dosing forms and strengths.
DOSAGE FORM | BENEFITS | STRENGTHS |
---|---|---|
Capsule | Oral medication available in gelatin or veggie capsule options. | 20 mg/cap to 50 mg/cap |
Chew Treat | Flavored, medicated oral soft chew treats. | 33 mg/chew |
Injectable Solution | Sterile solution intended for injection. | 50 mg/ml |
View all Guaifenesin options