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Liquid Chlor with Squalene for Dogs

By Barbara Forney, VMD

Last reviewed: 7/13/2022

Commonly prescribed for: Bacterial Infection

Species: Dogs

Therapeutic Class: Antibiotic Combination

General Drug Information and Indications

Liquid chlor with squalane is a combination product that is used to treat dogs with bacterial infections of the outer portion of the ear (otitis externa). Liquid chlor with squalane contains an antibiotic (chloramphenicol), a corticosteroid (prednisolone), a local anesthetic (tetracaine) and squalane. The chloramphenicol is for the bacterial infection; the prednisolone helps decrease the inflammation; the tetracaine numbs the ear canal to decrease any pain; and the squalane is useful for softening and dissolving wax and debris in the external ear canal. Liquid chlor does not have an antifungal drug so it is not used to treat yeast or fungal infections. Like many other drugs in veterinary medicine, this drug is not FDA approved for use in animals and is not available from a veterinary pharmaceutical manufacturer. Instead, it is compounded by a specialty pharmacy.

How to Give this Medication

Give this medication to your pet exactly as your veterinarian prescribes. If you miss giving your pet a dose of Liquid chlor with squalane, give the next dose as soon as you remember or, if it is close to the next scheduled dose, return to the regular schedule. Do not double dose to catch up.

Avoid contact with the medication when administering to your pet. Wash your hands thoroughly and immediately after giving your pet this medication.

Side Effects

Be sure to discuss any side-effects with your veterinarian immediately.

Some animals are sensitive to topical anesthetics, such as tetracaine. Be sure to tell your veterinarian if the medication is not working or seems to make the problem worse.


Keep this and all drugs out of reach of children. Liquid chlor with squalane is a prescription drug and should be used according to your veterinarian’s directions. It should only be used on the animal for which it was prescribed. Do not use this medication on a person.

This product should not be used in animals with a ruptured eardrum. Your veterinarian will look in your dog’s ear to evaluate the eardrum.

Drug Interactions

Be sure to review with your veterinarian any medications or supplements your dog may be receiving.

Corticosteroids applied into the ear are also absorbed into the bloodstream . This could be significant in pets that are also receiving corticosteroids by mouth or injection.


If you suspect your pet or another animal was overdosed accidentally or has eaten this medication inadvertently, contact your veterinarian or the A.S.P.C.A.’s Animal Poison Control Center at 888.426.4435. Always bring the prescription container with you when you take your pet for treatment.

If you or someone else has accidentally ingested this medication call the National Capital Poison Center at 800.222.1222.


Different strengths or dosage forms of liquid chlor with squalane may have different storage requirements. Read the labeling or ask your pharmacist for the storage requirements of the prescription you receive.
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