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Mexiletine for Dogs

By Barbara Forney, VMD

Last reviewed: 7/13/2022

Commonly prescribed for: Ventricular arrhythmias

Species: Dogs

Therapeutic Class: Oral antiarrhythmic

Basic Information

Mexiletine is a Class 1B, sodium channel blocker, anti-arrhythmia drug that is used to treat chronic ventricular arrhythmias in the dog. The mechanism of action is similar to lidocaine. Mexiletine is used to treat ventricular arrhythmias including PVC’s and ventricular tachycardia. If an animal has responded well to lidocaine during an acute episode, it is likely to respond well to mexiletine. Mexiletine is well-absorbed orally and has a bioavailability of approximately 85%. It is primarily excreted in the urine although approximately 10% is metabolized by the liver and excreted in the feces. The half-life of this drug may be prolonged in animals with reduced cardiac output, or after an acute myocardial infarction. The half-life may also be prolonged in animals with hepatic dysfunction or severe kidney disease.


The most-commonly used oral drugs for the chronic treatment of ventricular arrhythmias are atenolol, sotalol, procainamide, amiodarone, and mexiletine. Mexiletine may be combined with either atenolol or sotalol in instances when monotherapy is not adequate. Mexiletine may be used to treat inherited cardiomyopathy in Boxers and dilated cardiomyopathy in Doberman pinschers. A positive response to therapy would be an 85% reduction of ventricular premature contractions. The complete elimination of ventricular arrhythmia is not considered a realistic goal.

Side Effects

  • The most-common side effects are related to the GI tract including nausea and vomiting. Giving food with mexiletine has been shown to decrease the incidence of GI side effects.
  • Other possible side-effects include central nervous system signs such as dizziness, loss of balance and trembling, shortness of breath, and cardiac signs including PVCs or chest pain.
  • Rare side-effects reported in humans include seizures, and bone-marrow suppression.


Mexiletine should be used with extreme caution in animals with the following conditions: 2nd or 3rd degree AV heart block, intraventricular conduction abnormality, sinus node function abnormality, cardiogenic shock, congestive heart failure, myocardial infarction, liver dysfunction, hypotension, or seizure disorders.

Drug Interactions

  • Concurrent use with lidocaine increases the likelihood of adverse effects.
  • There are a number of drugs that may cause drug interactions either through changing the rate of absorption or changing the rate of metabolism of mexiletine. This list includes: antacids, atropine, opiates, cimetidine, griseofulvin, metoclopramide, phenobarbital, phenytoin, primidone, rifampin, theophylline.
  • Drugs that change urinary acidity may affect the renal excretion of mexiletine. These drugs include methionine, ammonium chloride, potassium phosphate, sodium phosphate, citrates, sodium bicarbonate, and carbonic anhydrase inhibitors.


Overdose with mexiletine carries a significant risk of toxicity. It is reported in the human literature that central nervous system signs precede cardiovascular signs. In experimental work in dogs, a four-fold overdose consistently produced CNS signs within 10 minutes of oral administration. If recognized in time, GI-emptying protocol should be attempted in conjunction with urinary acidification and supportive care.
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