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Aminopentamide Hydrogen Sulfate for Dogs and Cats


General Drug Information and Indications
How to Give this Medication
Side Effects
Drug Interactions
Who is Wedgewood Pharmacy and what is compounding?
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General Drug Information and Indications

Aminopentamide hydrogen sulfate is a drug which is used to control vomiting, diarrhea, and gastrointestinal (GI) pain or spasms in dogs and cats. It works by decreasing motility and smooth muscle contractions in the GI tract. It may be given orally or your veterinarian may give it by injection. Aminopentamide hydrogen sulfate was marketed under the trade name of Centrine® and is FDA approved for use in dogs and cats. This drug is not available from a veterinary pharmaceutical manufacturer. Instead, it is compounded by a specialty pharmacy (What is compounding?).

How to Give this Medication

Give this medication to your pet exactly as your veterinarian prescribes. If you miss giving your pet a dose of aminopentamide hydrogen sulfate, give the next dose as soon as you remember or, if it is close to the next scheduled dose, return to the regular schedule. Do not double dose to catch up.

Wash your hands after giving your pet this medication.

Side Effects

Be sure to discuss any side effects with your veterinarian immediately.

The most common side effects are dry mouth, dry eyes, and blurring of vision.

Less commonly your pet may develop delayed emptying of the stomach and GI tract. The medical term for this is illeus. Your pet may also develop hesitancy or difficulty urinating.


Keep this and all drugs out of reach of children. Aminopentamide hydrogen sulfate is a prescription drug and should be used according to your veterinarian’s directions. It should only be given to the animal for which it was prescribed. Do not give this medication to a person.

Aminopentamide hydrogen sulfate should not be used in animals with glaucoma. It should also be avoided in animals with stomach obstruction, intestinal obstruction, GI infections such as parvovirus, urinary obstruction, heart diseases, hyperthyroidism, high blood pressure or liver or kidney disease.

Aminopentamide hydrogen sulfate should not be used in elderly, pregnant, lactating or pediatric patients.

Drug Interactions

Be sure to review with your veterinarian any medications or supplements your pet may be receiving.

Antihistamines, procainamide, quinidine, meperidine, and certain tranquilizers may increase the effects of aminopentamide hydrogen sulfate.

Aminopentamide hydrogen sulfate may increase the effects of the following drugs: nitrofurantoin, phenylpropanolamine, and some diuretics.

Aminopentamide hydrogen sulfate may interfere with the action of metoclopramide.


If you suspect your pet or another animal was accidentally overdosed or has eaten this medication inadvertently, contact your veterinarian or the A.S.P.C.A.’s Animal Poison Control Center at 888.426.4435. Always bring the prescription container with you when you take your pet for treatment.

If you or someone else has accidentally ingested this medication call the National Capital Poison Center at 800.222.1222.


Different strengths or dosage forms of aminopentamide hydrogen sulfate may have different storage requirements. Read the labeling or ask your pharmacist for the storage requirements of the prescription you receive.

The information contained on this site is general in nature and is intended for use as an informational aid. It does not cover all possible uses, actions, precautions, side effects, or interactions of the products shown, nor is the information intended as medical advice or diagnosis for individual health problems or for making an evaluation as to the risks and benefits of using a particular product. You should consult your doctor about diagnosis and treatment of any health problems. Information and statements have not been evaluated by the Food and Drug Administration ("FDA"), nor has the FDA approved the products to diagnose, cure or prevent disease. 

Wedgewood Pharmacy compounded veterinary preparations are not intended for use in food and food-producing animals.
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About the Author

Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.

She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.

Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.