405 Heron Drive Suite 200
Swedesboro, NJ 08085
Ph 800.331.8272

Pharmacokinetics of oral gabapentin in Greyhound dogs

Vet J. Author manuscript; available in PMC 2012 January 1.

Published in final edited form as: Vet J. 2011 January; 187(1): 133–135.

Published online 2009 October 23. doi:  10.1016/j.tvjl.2009.09.022  


Butch KuKanich and Rachael L Cohen Author information  Copyright and License information  The publisher's final edited version of this article is available at Vet J


Keywords: Analgesic, Anticonvulsant, Veterinary, Dog, Pharmacology

The purpose of this study was to assess the pharmacokinetics of gabapentin in healthy Greyhound dogs after single oral doses targeted at 10 and 20 mg/kg PO. Six healthy Greyhounds were enrolled (3 males, 3 females). Blood was obtained at predetermined times for the measurement of gabapentin plasma concentrations by liquid chromatography/mass spectrometry. Pharmacokinetic parameters were determined with computer software. The actual mean (and range) doses administered were 10.2 (9.1–12.0) mg/kg and 20.5 (18.2 – 24) mg/kg for the 10 mg/kg and 20 mg/kg targeted dose groups. The mean CMAX for the 10 and 20 mg/kg groups were 8.54 and 13.22 μg/mL at 1.3 and 1.5 h, and the terminal half-lives were 3.3 and 3.4 h, respectively. The relative bioavailability of the 10 mg/kg group was 1.13 compared to the 20 mg/kg group. Gabapentin was rapidly absorbed and eliminated in dogs indicating frequent dosing is needed to maintain minimum targeted plasma concentrations.  

To read more, please click here.

Looking for Gabapentin?

We can let your veterinarian know that you are interested in our compounded Gabapentin.

Have a written prescription from your veterinarian?
Get your instant quote by chat!